A clinical case series: Evaluation of a Bioactive Microfibre Gelling (BMG™) dressing to support improved service delivery in the management of chronic wounds in a wound healing clinic.

Abstract Introduction

Like many sectors tissue viability services have been affected by and had to learn lessons from the COVID-19 pandemic. The pandemic has had an impact on service delivery and patient communication and there has been some debate over whether this will permanently change the ways in which care is delivered. [1]

As a tissue viability team, we are constantly striving to improve service delivery, healing rates and positive patient outcomes. In 2021 we were introduced to a unique Bioactive Microfibre Gelling (BMG) dressing, Maxiocel® that utilises chitosan to maintain a cohesive structure to increase fluid handling, antimicrobial and wound healing properties.

Chitosan has haemostatic action due to the rapid absorption of blood plasma that leads to a concentration of erythrocytes and platelets to the site of injury, followed by platelet activation and erythrocyte coagulation[2]. It promotes re-epithelialisation by stimulating the proliferation of dermal fibroblasts and inhibiting the proliferation of keratinocytes.[3] It can also protect the skin extracellular matrix by blocking the MMP-2 expression thus aiding wound healing.[4]

Our aim was to implement an evaluation of this dressing to determine the possible impact for patients with long standing chronic non-healing wounds within our wound healing clinic.


Following trust guidelines and gaining patient consent eleven patients having chronic wounds with various aetiologies and wound durations were enrolled in the evaluation. Each week, over a four week period, the wounds were assessed for; wound area reduction, type of tissue present on the wound, exudate management, periwound skin condition and wound pain.

Dressing changes ranged from daily to weekly depending on the wound conditions.


Over a 4 week evaluation period, all patients showed a significant improvement in:

  • Wound parameters.
  • Average tissue type at start of treatment >75% nectrotic / sloughy. Reducing to 17% by week four.
  • Granulation and epithelialising tissue – from 20% on day 0 to >80% on week four.
  • Exudate levels reduced from “very heavy” and heavy” to “low “ and ”dry” wounds.
  • Improvement in peri-wound skin from “mostly macerated” on week zero to “healthy” on week four, due to superior exudate locking ability of the dressing.
  • “Complete” or “Almost healed” in 6 out of 11 patients.
  • 5 in 11 patients reported “healing” wounds.
  • Most interestingly, significant reduction in pain scores was reported in all patients.
  • Average pain score was 5.8±2.7 at the start of the evaluation. After three weeks mean wound pain in all the patients improved significantly to 2.5±1.9.

All these wounds were static or deteriorating before the initiation of the study. The phenomenal increase in granulating and epithelialising tissue was seen as soon as one week after the treatment initiation, together with improvements in periwound skin condition and level of exudate.

The overall rating of the dressing was given as “good” or “very good” for all of the following usage related parameters: – ease of understanding the instructions for use, ease of application, exudate absorption capabilities, ease of removal and ability to remove dressing in one piece.

Significant clinical improvement was seen within just 4 weeks*

Graphs showing pain reduction and wound improvements with MaxioCel dressing


Overall, MaxioCel has shown beneficial effects in chronic non-healing wounds of surgical, venous disease, pressure, and diabetic aetiologies. The primary and secondary goals of using this bioactive microfibre gelling dressing to improve wound healing and therefore service delivery were achieved.


The complicated wounds seen in this study were previously non-healing and MaxioCel, with BMG technology, demonstrated significant clinical improvement within just 4 weeks resulting in its addition to our wound care formulary in October 2022.

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[1] Fletcher, J Atkin, L Murphy, N Murray, S Ousey, K Sandoz, H The Lessons learned from COVID-19: Building a ‘new normal’ in tissue viability Wounds UK | Vol 17 | No 3 | 2021

[2] M. Kabeer, P.P. Venugopalan, V.C. Subhash, Pre-hospital Hemorrhagic Control Effectiveness of Axiostat® Dressing Versus Conventional Method in Acute Hemorrhage Due to Trauma, Cureus. 11 (2019).

[3] G.I. Howling, P.W. Dettmar, P.A. Goddard, F.C. Hampson, M. Dornish, E.J. Wood, The effect of chitin and chitosan on the proliferation of human skin fibroblasts and keratinocytes in vitro, Biomaterials. 22 (2001) 2959–2966.

[4] E. Baena, S.R. Cunha, T. Maravić, A. Comba, F. Paganelli, G. Alessandri-Bonetti, L. Ceballos, F.R. Tay, L. Breschi, A. Mazzoni, Effect of chitosan as a cross-linker on matrix metalloproteinase activity and bond stability with different adhesive systems, Mar. Drugs. 18 (2020) 263.